Cortisone can weaken the immune system. For this reason, many doctors limit injections to once every 3 months for a specific joint, and 6 times a year for the entire body. Cortisone can also raise blood sugar levels in people with diabetes. If you have diabetes, cortisone injections can raise your blood sugar. If you have an infection, these shots can make it harder to recover. If you have an infection, these shots can make it harder.
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