• Digoxin elixir bioavailability

    Digoxin, sold under the brand name Lanoxin among others, is a medication used to treat various heart conditions. Most frequently it is used for atrial fibrillation, atrial flutter, and heart failure. Digoxin is taken by mouth or by injection into a vein.. Common side effects include breast enlargement with other side effects generally due to an excessive dose. The bioavailability of orally administered digoxin is approximately 63 % in tablet form and 75 % as oral solution. Distribution The initial distribution of digoxin from the central to the peripheral compartment generally lasts from 6 to 8 h. McAuley, GlobalRPh Inc. There are many problems encountered in a program to effectively dose a drug such as digoxin. It is inherently difficult because of such components as narrow therapeutic index, difficult to define therapeutic endpoints, inter and intra-patient variability, and effects of pathological states and drugs on digoxin’s disposition. Jun 15,  · Digoxin is incompletely absorbed (oral dose) and has a substantial fraction cleared by kidneys with % excreted in urine unchanged [22, 23, 25]. The bioavailability of digoxin varies from 50% to more than 90% of the oral dose [4, 23, 25] although this increases for gelatin capsules to nearly % (intravenous is assumed to be %) [4, 25]. mean volume of distribution was L/kg. Digoxin elixir was rapidly absorbed, with a mean bioavailability estimate of +/- % SD. Digoxin tablets were less rapidly and less completely absorbed, with a mean bioavailability estimate of +/- %. Data collected in this series of experiments and data from the. Apr 01,  · Absorption of digoxin from Digoxin Tablets has been demonstrated to be 60% to 80% complete compared to an identical intravenous dose of digoxin (absolute bioavailability) or digoxin solution in capsules (relative bioavailability).6/ Absolute bioavailability of digoxin is as follows: Tablets—60 to 80%; elixir—70 to 85%; liquid-filled capsules—90 to %; and intravenous injection—% {01}. The doses of digoxin are considered equivalent {01}. bioavailability of digoxin from the elixir formulation is 70 to 85%, similar to that seen (in adults) with standard tablets (60 to 80%).When the elixir is taken after meals, the peak serum File Size: 86KB. In tablet form, the bioavailability ranges from (50%) to more than (90%); a value of (70%) is often used as a standard for digoxin tablets. 28 While soft-gelatin digoxin capsules seem to be completely absorbed (bioavailability =), digoxin elixir exhibits a bioavailability of approximately 80% (). 28 Administered intravenously, digoxin is assumed to have a bioavailability of % ().
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