What is the half life of Bactrim DS? The mean serum half-lives of sulfamethoxazole and trimethoprim are 10 and 8 to 10 hours, respectively. However, patients with severely impaired renal function exhibit an increase in the half-lives of both components, dosage regimen adjustment (see DOSAGE AND ADMINISTRATION section).3/5(1). Pyelonephritis: 1 DS tab or 2 regular-strength tabs PO q12hr x 14 days. Prostatitis: 1 DS tab or 2 regular-strength tabs PO q12hr x 14 days or months if chronic infection. A 3 to 5 day course may be used for acute, uncomplicated cystitis. Prophylaxis (off-label): Various regimens exist; may use regular-strength tablet once/twice per week.
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