a 10 mg oral dose of hydrocodone administered to five adult male subjects, the mean peak concentration was ± ng/mL. Maximum serum levels were achieved at ± hours and the half-life was determined to be ± hours/ Acetaminophen-hydrocodone should be used with caution in elderly or debilitated patients and those with hypothyroidism, Addison's disease, prostatic hypertrophy or urethral stricture; generally, start at the lower end of the range and titrate carefully. Maximum Acetaminophen Dose is 4 g in 24 hours/
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